Danazol has rarely caused very serious possibly fatal blood clots such as stroke liver disease, and increased pressure on the brain benign intracranial hypertension. You should not use this medication if you are allergic to danazol, or if you have porphyria, a history of stroke or blood clot, or severe problems with your heart, liver, or kidney. You also should not take danazol if you are pregnant or breast-feeding, if you have breast or uterine cancer, or if you have abnormal vaginal bleeding that has not been checked by a doctor. Do not use Danocrine if you are pregnant. Tell your doctor if you become pregnant during treatment. Before you start taking Danocrine, you may need to have a to make sure you are not pregnant. Use an effective barrier form of birth control such as a condom or with spermicide gel or inserts. Hormonal contraception such as birth control pills, injections, implants, skin patches, and vaginal rings may not be effective to prevent pregnancy during treatment. Breastfeeding is not recommended while using this drug.
Danazol therapy. These alterations may be marked, and prescribers should consider the potential impact on the risk of atherosclerosis and coronary artery disease in accordance with the potential benefit of the therapy to the patient. Metabolic side effects have included significant increases in low density lipoproteins LDL and decreases in high density lipoproteins HDL. Decreased glucose tolerance requiring adjustments in hyperglycemic control has occurred. Capsules of 200 mg orange bottles of 100 NDC 0024-0305-06.
Take danazol by mouth with or without food. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Danazol has been associated with several cases of benign intracranial hypertension also known as pseudotumor cerebri. Early signs and symptoms of benign intracranial hypertension include papilledema, headache, nausea and vomiting, and visual disturbances. Patients with these symptoms should be screened for papilledema and, if present, the patients should be advised to discontinue danazol immediately and be referred to a neurologist for further diagnosis and care.
Gastrointestinal side effects have included nausea and vomiting. Rare cases of pancreatitis have been reported. The total daily dosage of Danocrine for fibrocystic breast disease ranges from 100 mg to 400 mg given in two divided doses depending upon patient response. Therapy should begin during menstruation. Otherwise, appropriate tests should be performed to ensure that the patient is not pregnant while on therapy with Danocrine. A nonhormonal method of contraception is recommended when Danocrine is administered at this dose, since ovulation may not be suppressed. Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.
Danocrine in the early 90's to treat endometriosis. I was supposed to take it for about 9 months to "simulate pregnancy" by stopping my menstrual cycle long enough to "heal". I could only do it for 3 months, because the side effects were awful. Seffart G ed. "Drug Dosage in Renal Insufficiency. What should I discuss with my healthcare provider before taking Danocrine danazol? Cardiovascular side effects have included edema and congestive heart failure. Danocrine can induce ALA synthetase activity and hence porphyrin metabolism.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. You must start taking this medicine while you are having your monthly period. Danocrine capsules for oral administration contain 50 mg, 100 mg or 200 mg danazol. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs. It is essential that therapy continue uninterrupted for 3 to 6 months but may be extended to 9 months if necessary. After termination of therapy, if symptoms recur, treatment can be reinstituted. To assure that the patient is not pregnant, therapy should be initiated during menstruation. If this is not possible, a sensitive pregnancy test that detects early pregnancy should be done to insure the patient is not pregnant. A non- hormonal birth control method is recommended. Endocrine side effects have included the inhibition of estrogen synthesis, resulting in flushing, sweating, vaginal dryness and irritation, and reduction in breast size. During administration of danazol the active ingredient contained in Danocrine endogenous testosterone synthesis and release may be inhibited through feedback inhibition of pituitary luteinizing hormone LH. Large doses of danazol may suppress spermatogenesis through inhibition of pituitary follicle stimulating hormone FSH. Danazol may decrease levels of thyroxine-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged and there is no clinical evidence of thyroid dysfunction. If this occurs, the drug should be discontinued. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The information contained in the Truven Health Micromedex products as delivered by Drugs. It should not be given intravenously. amiloride
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. The oral liquid form of sirolimus must be mixed with water or orange juice only. Do not use any other liquids to mix this medicine. Do not mix this medicine with grapefruit juice or potentially dangerous effects may result. Avoid eating grapefruit or drinking grapefruit juice while you are taking sirolimus. Do not crush, chew, or break a sirolimus tablet. Tell your doctor if you have trouble swallowing the tablet whole. If therapy is not initiated during menstruation, a sensitive pregnancy test that detects early pregnancy should be done to determine that the patient is not pregnant. A non-hormonal contraceptive method should be used during danazol therapy. If pregnancy occurs during therapy, danazol should be discontinued. Patients should be advised of the possible risks to the fetus. Ronnberg L, Jarvinen PA "Pregnancy rates following various therapy modes for endometriosis in infertile patients. Because Danocrine may cause some degree of fluid retention, conditions that might be influenced by this factor, such as epilepsy, migraine, or cardiac or renal dysfunction, polycythemia and hypertension require careful observation. Use with caution in patients with diabetes mellitus. Miller EJ, Coleman FH "Pseudohypertestosteronemia during danazol therapy. A case report. Duck SC, Katayama KP "Danazol may cause female pseudohermaphroditism. Wentz AC "Adverse effects of danazol in pregnancy. Other side effects in female patients have included virilization, including deepening voice, hirsutism, acne, clitomegaly rare and menstrual abnormalities, due the androgenic activity of danazol the active ingredient contained in Danocrine Discontinuation of danazol at signs of mild virilization may prevent irreversible virilization. Reduction in breast size may occur due to decreased estrogen synthesis. How should I take Danocrine danazol? Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. Abnormalities in laboratory tests may occur during therapy with Danocrine including CPK, glucose tolerance, glucagon, thyroid binding globulin, sex hormone binding globulin, other plasma proteins, lipids and lipoproteins. acka.info abilify
Check with your doctor right away if you are a female and have a larger clitoris sexual organ deepening of your voice, or unusual hair growth after taking danazol. Your doctor may advise you to stop taking the medicine so these side effects do not get worse. Your pharmacist can provide more information about sirolimus. Danazol may raise the plasma levels of cyclosporin and tacrolimus, leading to an increase of the renal toxicity of these drugs. Monitoring of systemic concentrations of these drugs and appropriate dose adjustments may be needed when used concomitantly with Danazol. Ask your healthcare professional how you should dispose of any medicine you do not use. DANOCRINE, persistent amenorrhea has occasionally been reported. This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using danazol. Undiagnosed abnormal genital bleeding. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. Johnson KF "Splenomegaly and an abnormal peripheral smear associated with the use of danazol: case report. Kingsbury AC "Danazol and fetal masculinization: a warning. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; abnormal hair growth; burning, numbness, or tingling; calf or leg pain, redness, tenderness, or swelling; chest pain; dizziness; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; headache; mental or mood changes eg mood swings, nervousness; nausea; red, swollen, blistered, or peeling skin; seizures; shortness of breath; sudden, unexplained weight gain; swelling of the hands, ankles, legs, or feet; symptoms of liver problems eg, yellowing of the skin or eyes, dark urine, pale stools, stomach pain, loss of appetite, unusual tiredness; symptoms of stroke eg, one-sided weakness, slurred speech, confusion; unusual bleeding or bruising; vision problems; vomiting. Genitourinary side effects have included oligospermia and decreased ejaculatory volume. Elderly male patients may experience prostatic enlargement resulting in urinary obstruction. Priapism and excessive stimulation may develop. In moderate to severe disease, or in patients due to endometriosis, a starting dose of 800 mg Danocrine given in two divided doses is recommended. The total daily dosage of Danocrine for fibrocystic breast disease ranges from 100 mg to 400 mg given in two divided doses depending upon patient response. This list is not complete and other drugs may interact with danazol. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Kahn H, Manzarbeitia C, Theise N, et al "Danazol-induced hepatocellular adenomas: A case report and review of the literature. What should I avoid while taking sirolimus Rapamune? Danazol is used to treat endometriosis and fibrocystic breast disease. Danazol is also used to prevent attacks of angioedema in people with an inherited form of this disorder hereditary angioedema. Danazol can cause insulin resistance. Caution should be exercised when used with antidiabetic drugs. Use of danazol in pregnancy is contraindicated. What should I avoid while taking danazol Danocrine? How should I take danazol Danocrine? Do not use danazol if you are pregnant. It may cause serious harm to a fetus. It is recommended that a pregnancy test be performed before starting danazol. Effective, nonhormonal birth control measures, such as diaphragms and condoms, should be used while taking danazol. Talk with your doctor about the use of effective birth control while you use danazol. If you become pregnant while taking danazol, stop use and contact your doctor right away. Sirolimus may cause a serious viral infection of the brain that can lead to disability or death. This risk is higher if you have a weak immune system or are receiving certain medicines. Call your doctor right away if you have any change in your mental state, problems with speech or walking, or decreased vision. These symptoms may start gradually and get worse quickly. Other possible endocrine effects are menstrual disturbances including spotting, alteration of the timing of the cycle and amenorrhea. Although cyclical bleeding and ovulation usually return within 60 to 90 days after discontinuation of therapy with Danazol, persistent amenorrhea has occasionally been reported. Taking danazol to treat endometriosis may increase your risk of ovarian cancer. Talk with your doctor about your individual risk. If you experience bloating or swelling of the ankles, fainting or dizziness, headache, weakness, fatigue, irregular heartbeat, difficulty speaking, double vision, stomach pain, changes in the frequency of bowel movements, persistent sore throat or fever, joint pain or leg cramps, fever, yellowing of the skin, or dark urine, contact your doctor. It may be necessary to monitor your blood levels of carbamazepine. Your doctor may want to adjust the dose of your medicine. walmart brand for champix
Androgen like effects include weight gain, acne and seborrhea. Mild hirsutism, edema, hair loss, voice change, which may take the form of hoarseness, sore throat or of instability or deepening of pitch, may occur and may persist after cessation of therapy. Hypertrophy of the clitoris is rare. What are the possible side effects of sirolimus Rapamune? Additionally a non-hormonal method of contraception should be used during therapy. If a patient becomes pregnant while taking danazol, administration of the drug should be discontinued and the patient should be apprised of the potential risk to the fetus. Exposure to danazol in utero may result in androgenic effects on the female fetus; reports of clitoral hypertrophy, labial fusion, urogenital sinus defect, vaginal atresia, and ambiguous genitalia have been received. Miyata T, Tamechika Y, Torisu M "Ischemic colitis in a 33-year-old woman on danazol treatment for endometriosis. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. National Library of Medicine and Drugs. Peress MR, Kreutner AK, Mathur RS, Williamson HO "Female pseudohermaphroditism with somatic chromosomal anomaly in association with in utero exposure to danazol. To assure that the patient is not pregnant, therapy should be initiated during menstruation. If this is not possible, a sensitive pregnancy test that detects early pregnancy should be done to insure the patient is not pregnant. A non-hormonal birth control method is recommended. Hematologic side effects have included thromboembolic and thrombophlebotic events including sagittal sinus thrombosis some resulting in fatal strokes, and increased red cell production. The toxic effects of your carbamazepine may increase. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. When these two medicines are taken together, your body may not process carbamazepine properly. order clarinex for
What happens if I overdose Danocrine? Do not use any other liquids to mix this medicine. The presence of other medical problems may affect the use of this medicine. Use a barrier form of birth control such as a condom or diaphragm with spermicide. Hormonal contraception such as birth control pills, injections, implants, skin patches, and vaginal rings may not be effective enough to prevent pregnancy during your treatment with danazol. Bioavailability studies indicate that blood levels do not increase proportionally with increases in the administered dose. Danocrine, persistent amenorrhea has occasionally been reported. Wardle PG, Whitehead MI, Mills RP "Non-reversible and wide ranging voice changes after treatment with danazol. To assure a female patient is not pregnant, therapy should be initiated during menstruation. If this is not possible, a sensitive pregnancy test that detects early pregnancy should be done to insure the patient is not pregnant. A non- hormonal birth control method is recommended. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. FDA pregnancy category X. This medication can harm an unborn baby or cause vaginal birth defects in a newborn female infant. Do not use danazol if you are pregnant. Stop taking danazol and tell your doctor right away if you become pregnant during treatment. Sirolimus can lower the blood cells that help your body fight infections. Avoid contact with people who have colds, the flu, or other contagious illnesses. Do not receive any vaccines without your doctor's advice. Contact your doctor immediately if you develop signs of infection. In most instances, breast pain and tenderness are significantly relieved by the first month and eliminated in 2 to 3 months. Usually elimination of nodularity requires 4 to 6 months of uninterrupted therapy. Regular menstrual patterns, irregular menstrual patterns, and amenorrhea each occur in approximately one-third of patients treated with 100 mg of Danazol capsules. Irregular menstrual patterns and amenorrhea are observed more frequently with higher doses. Clinical studies have demonstrated that 50% of patients may show evidence of recurrence of symptoms within one year. In this event, treatment may be reinstated. In moderate to severe disease, or in patients infertile due to endometriosis, a starting dose of 800 mg given in two divided doses is recommended. Amenorrhea and rapid response to painful symptoms is best achieved at this dosage level. Gradual downward titration to a dose sufficient to maintain amenorrhea may be considered depending upon patient response. For mild cases, an initial daily dose of 200 mg to 400 mg given in two divided doses is recommended and may be adjusted depending on patient response. Therapy should begin during menstruation. Otherwise, appropriate tests should be performed to ensure that the patient is not pregnant while on therapy with Danazol capsules see and . It is essential that therapy continue uninterrupted for 3 to 6 months but may be extended to 9 months if necessary. After termination of therapy, if symptoms recur, treatment can be reinstituted. Shaw RW, Farquhar JW "Female pseudohermaphroditism associated with danazol exposure in utero. Case report.
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Danocrine suppresses the pituitary-ovarian axis. This suppression is probably a combination of depressed hypothalamic-pituitary response to lowered estrogen production, the alteration of sex steroid metabolism, and interaction of danazol with sex hormone receptors. The only other demonstrable hormonal effect is weak androgenic activity. Danocrine depresses the output of both follicle-stimulating hormone FSH and luteinizing hormone LH. If you miss a dose of danazol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Following an initial favorable response amenorrhea develops the dosage should be titrated to the minimum dose that suppresses disease activity. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Williams G "Metabolic effects of danazol. Tell your doctor if your condition does not improve or if it worsens. Andriole GL, Brickman C, Lack EE, Sesterhenn IA, Javadpour N, Linehan WM, Frank MM "Danazol-induced cystitis: an undescribed source of hematuria in patients with hereditary angioneurotic edema. Castro-Magana M, Cheruvanky T, Collipp PJ, Ghavami-Maibodi Z, Angulo M, Stewart C "Transient adrenogenital syndrome due to exposure to danazol in utero. In this event, treatment may be reinstated. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. At first, 200 to 400 milligrams mg divided in two doses, for at least 3 to 6 months and up to 9 months. Your doctor may adjust your dose as needed and tolerated. In female patients, the use of danazol the active ingredient contained in Danocrine may result in virilization including deepening voice, hirsutism, acne, clitomegaly rare and menstrual abnormalities. Discontinuation of medication at signs of mild virilization may prevent irreversible virilization. Store sirolimus tablets at room temperature, away from heat, moisture, and light. mail order strattera pharmacy
Women who take danazol to treat endometriosis or fibrocystic breast disease should start the medication during a menstrual period. An overdose of danazol is not expected to produce life threatening symptoms. However, long term use of high doses can lead to symptoms such as weight gain, increased acne or facial hair, menstrual problems, or breast changes. Generally, the pituitary-suppressive action of Danocrine is reversible. Ovulation and cyclic bleeding usually return within 60 to 90 days when therapy with Danocrine is discontinued. What other drugs will affect sirolimus Rapamune? Stir the mixture and drink all of it right away. Overdose symptoms may include some of the serious side effects listed in this medication guide. celexa
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Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Some medical conditions may interact with danazol.
An overdose of danazol is not expected to produce life threatening symptoms. However, long term use of high doses can lead to symptoms such as weight gain, increased acne or facial hair, menstrual problems, or breast changes. What should I avoid while taking danazol? Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. If you think you have become pregnant while using the medicine, tell your doctor right away. Follow your doctor's instructions about any restrictions on food, beverages, or activity.
It may take several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve or if they get worse during treatment. Your doctor may adjust your dose as needed and tolerated. Laveder F, Marcolongo R, Zamboni S "Thrombocytopenic purpura following treatment with danazol.
FDA pregnancy category C. It is not known whether sirolimus will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Use effective birth control while you are using this medication and for at least 12 weeks after your treatment ends. What is danazol Danocrine? Do not stop taking any medications without consulting your healthcare provider.